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Article

Promoter polymorphism of FASL confers protection against female-specific cancers and those of FAS impact the cancers divergently.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Apr 2015

Nallapalle Sateesh Reddy, Daripally Sarika, Prasad V T S Vidudala

Abstract excerpt

We investigated risk association of FAS (-1377 G>A and -670 A>G) and FASL (-844 T>C) promoter polymorphisms with breast, ovarian, cervical, and endometrial cancers and report that the FASL -844 CC genotype was protective against breast, ovarian, cervical, and endometrial cancers (P ≤ 0.01). On the other hand, FAS -1377 GA and AA variants increased risk of breast cancer. However, the GA variant of FAS -1377 was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25472583
DOI: 10.1007/s13277-014-2896-7

Genes

FAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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