Article
In vivo repopulating activity emerges at the onset of hematopoietic specification during embryonic stem cell differentiation.
Stem cell reports - 10 Mar 2015
Pearson Stella, Cuvertino Sara, Fleury Maud, Lacaud Georges, Kouskoff Valerie
Abstract excerpt
The generation of in vivo repopulating hematopoietic cells from in vitro differentiating embryonic stem cells has remained a long-standing challenge. To date, hematopoietic engraftment has mostly been achieved through the enforced expression of ectopic transcription factors. Here, we describe serum-free culture conditions that allow the generation of in vivo repopulating hematopoietic cells in the absence of...
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