Article
Loss of vascular endothelial growth factor A (VEGFA) isoforms in the testes of male mice causes subfertility, reduces sperm numbers, and alters expression of genes that regulate undifferentiated spermatogonia.
Endocrinology - 1 Dec 2013
Lu Ningxia, Sargent Kevin M, Clopton Debra T, Pohlmeier William E, Brauer Vanessa M, McFee Renee M, Weber John S, Ferrara Napoleone, Silversides David W, Cupp Andrea S
Abstract excerpt
Vascular endothelial growth factor A (VEGFA) isoform treatment has been demonstrated to alter spermatogonial stem cell homeostasis. Therefore, we generated pDmrt1-Cre;Vegfa(-/-) (knockout, KO) mice by crossing pDmrt1-Cre mice to floxed Vegfa mice to test whether loss of all VEGFA isoforms in Sertoli and germ cells would impair spermatogenesis. When first mated, KO males took 14 days longer to get control females...
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