Article
CLARITY reveals dynamics of ovarian follicular architecture and vasculature in three-dimensions.
Scientific reports - 23 Mar 2017
Feng Yi, Cui Peng, Lu Xiaowei, Hsueh Brian, Möller Billig Fredrik, Zarnescu Yanez Livia, Tomer Raju, Boerboom Derek, Carmeliet Peter, Deisseroth Karl, Hsueh Aaron J W
Abstract excerpt
Optimal distribution of heterogeneous organelles and cell types within an organ is essential for physiological processes. Unique for the ovary, hormonally regulated folliculogenesis, ovulation, luteal formation/regression and associated vasculature changes lead to tissue remodeling during each reproductive cycle. Using the CLARITY approach and marker immunostaining, we identified individual follicles and corpora...
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