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Use of mouse models to investigate the contributions of CNVs associated with schizophrenia and autism to disease mechanisms.

Current opinion in genetics & development - 1 Jun 2021

Hyman Steven E

Abstract excerpt

Human genetics is providing much needed clues to mechanisms underlying neuropsychiatric disorders. Highly penetrant copy number variants (CNVs) were among the first genetic variants confidently associated with schizophrenia and autism spectrum disorders (ASDs). Despite their structural complexity, the high penetrance of CNVs associated with neuropsychiatric disorders suggested utility for construction of cellular...

Topics

Alleles
Animals
Autistic Disorder
Brain Diseases
DNA Copy Number Variations
Disease Models, Animal
Genetic Predisposition to Disease
Humans
Mice
Mice, Transgenic
Penetrance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Schizophrenia

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PMID: 33957550
DOI: 10.1016/j.gde.2021.03.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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