Article
COL4A1 mutations as a monogenic cause of cerebral small vessel disease: a systematic review.
Stroke - 1 Aug 2010
Lanfranconi Silvia, Markus Hugh S
Abstract excerpt
BACKGROUND AND PURPOSE: A number of single gene disorders can cause cerebral small vessel disease. Mutations in the COL4A1 gene encoding the type IV collagen alpha 1 chain, which are already associated with porencephaly and infantile hemiparesis, have been recently recognized as a further monogenic cause of small vessel disease that can present in adulthood. METHODS: We performed a systematic review of published...
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