COL4A2 is associated with lacunar ischemic stroke and deep ICH: Meta-analyses among 21,500 cases and 40,600 controls.

doi:10.1212/WNL.0000000000004560

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Article

COL4A2 is associated with lacunar ischemic stroke and deep ICH: Meta-analyses among 21,500 cases and 40,600 controls.

Neurology - 24 Oct 2017

Rannikmäe Kristiina, Sivakumaran Vhinoth, Millar Henry, Malik Rainer, Anderson Christopher D, Chong Mike, Dave Tushar, Falcone Guido J, Fernandez-Cadenas Israel, Jimenez-Conde Jordi, Lindgren Arne, Montaner Joan, O'Donnell Martin, Paré Guillaume, Radmanesh Farid, Rost Natalia S, Slowik Agnieszka, Söderholm Martin, Traylor Matthew, Pulit Sara L, Seshadri Sudha, Worrall Brad B, Woo Daniel, Markus Hugh S, Mitchell Braxton D, Dichgans Martin, Rosand Jonathan, Sudlow Cathie L M

Abstract excerpt

OBJECTIVE: To determine whether common variants in familial cerebral small vessel disease (SVD) genes confer risk of sporadic cerebral SVD. METHODS: We meta-analyzed genotype data from individuals of European ancestry to determine associations of common single nucleotide polymorphisms (SNPs) in 6 familial cerebral SVD genes (COL4A1, COL4A2, NOTCH3, HTRA1, TREX1, and CECR1) with intracerebral hemorrhage (ICH)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28954878
DOI: 10.1212/WNL.0000000000004560
PMCID: PMC5664302

Genes

HTRA1
NOTCH3
TREX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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