Article
Wnt3a signal pathways activate MyoD expression by targeting <i>cis</i>-elements inside and outside its distal enhancer
5 Feb 2015
Abstract excerpt
Wnt proteins are secreted cytokines and several Wnts are expressed in the developing somites and surrounding tissues. Without proper Wnt stimulation, the organization of the dermomyotome and myotome can become defective. These Wnt signals received by somitic cells can lead to activation of Pax3/Pax7 and myogenic regulatory factors (MRFs), especially Myf5 and MyoD. However, it is currently unknown whether Wnts...
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