Article
No renal phenotype in human phospholipid transfer protein transgenic apolipoprotein E deficient mice despite severe aortic atherosclerosis.
Clinical laboratory - 1 Jan 2014
Dullaart Robin P F, Van Haperen Rien, Van Den Born Jaap, Van Goor Harry, De Crom Rini, Van Tol Arie
Abstract excerpt
BACKGROUND: Phospholipid transfer protein (PLTP) is an emerging cardiometabolic risk factor. Plasma PLTP is elevated in humans with end-stage kidney disease and glomerular proteinuria, but the contribution of systemic PLTP elevation to the development of renal damage is unknown. We tested whether human PLTP expression in ApoE deficient mice (an atherosclerosis-prone model) results in renal insufficiency,...
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