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Pharmacogenetic and Association Studies on the Influence of HLA Alleles and Rivastigmine on the Iranian Patients with Late-Onset Alzheimer's Disease.

Molecular neurobiology - 1 Jun 2021

Rezaei Rad Fatemeh, Ghahvechi Akbari Masood, Zamani Majid, Bayat Shiva, Zamani Mahdi

Abstract excerpt

Alzheimer's disease (AD) is a progressive neurodegenerative disorder affecting cognitive function. A number of allelic genes from HLA complex have shown variable associations with AD in different populations. In this study, we investigated the association of DQB1*06:00/x, DRB1*04:00/x, DRB1*15:00/x, and B*07:00/x genotypes with AD and their relevance to the efficacy of rivastigmine treatment in the Iranian...

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PMID: 33502736
DOI: 10.1007/s12035-021-02295-z

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