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Article

Identifying genetic loci associated with antidepressant drug response with drug-gene interaction models in a population-based study.

Journal of psychiatric research - 1 Mar 2015

Noordam Raymond, Direk Nese, Sitlani Colleen M, Aarts Nikkie, Tiemeier Henning, Hofman Albert, Uitterlinden André G, Psaty Bruce M, Stricker Bruno H, Visser Loes E

Abstract excerpt

It has been difficult to identify genes affecting drug response to Selective Serotonin Reuptake Inhibitors (SSRIs). We used multiple cross-sectional assessments of depressive symptoms in a population-based study to identify potential genetic interactions with SSRIs as a model to study genetic variants associated with SSRI response. This study, embedded in the prospective Rotterdam Study, included all successfully...

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Source

Identifiers

PMID: 25649181
DOI: 10.1016/j.jpsychires.2015.01.005

Genes

FSHR
HMGB4
PLCB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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