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Hotspot mutations and genomic expansion of ERG11 are major mechanisms of azole resistance in environmental and human commensal isolates of Candida tropicalis.

International journal of antimicrobial agents - 1 Dec 2023

Hu Tianren, Wang Sijia, Bing Jian, Zheng Qiushi, Du Han, Li Chao, Guan Zhangyue, Bai Feng-Yan, Nobile Clarissa J, Chu Haiqing, Huang Guanghua

Abstract excerpt

OBJECTIVES: Infections caused by azole-resistant Candida tropicalis strains are increasing in clinical settings. The reason for this epidemical change and the mechanisms of C. tropicalis azole resistance are not fully understood. METHODS: In this study, we performed biological and genomic analyses of 239 C. tropicalis strains, including 115 environmental and 124 human commensal isolates. RESULTS: Most (99.2%) of...

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Antifungal Agents
Azoles
Candida tropicalis
Drug Resistance, Fungal
Fluconazole

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Fungal Proteins

Microbial Sensitivity Tests

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PMID: 37863341
DOI: 10.1016/j.ijantimicag.2023.107010

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