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Article

Synthesis and biological evaluation of α-aryl-α-tetralone derivatives as hepatitis C virus inhibitors.

European journal of medicinal chemistry - 26 Mar 2015

Manvar Dinesh, Fernandes Talita de A, Domingos Jorge L O, Baljinnyam Erdenechimeg, Basu Amartya, Junior Eurides F T, Costa Paulo R R, Kaushik-Basu Neerja

Abstract excerpt

The synthesis of a novel series of 1-carba-isoflavanones through the α-arylation of α-tetralones is described. Several of these compounds demonstrated potent activity and selectivity in-vitro against HCV replicon reporter cells. Compound 10 (LQB-314) exhibited the best profile being active and selective in both replicon reporter cells (IC50 1.8 μM, SI > 111 and IC50 4.3 μM, SI > 46 in Huh7/Rep-Feo1b and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25644675
DOI: 10.1016/j.ejmech.2015.01.057

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FGR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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