Article
Potent bisimidazole-based HCV NS5A inhibitors bearing annulated tricyclic motifs.
Bioorganic & medicinal chemistry letters - 15 Dec 2014
Zhong Min, Peng Eric, Huang Ningwu, Huang Qi, Huq Anja, Lau Meiyen, Colonno Richard, Li Leping
Abstract excerpt
This Letter describes the synthesis and biological evaluation of a number of functionalized bisimidazoles bearing annulated tricyclic motifs as potent inhibitors of HCV NS5A protein. Compound 4 h, which contains a substituted tricyclic 6-6-6 xanthene, demonstrated broad genotypic spectrum, compelling potency, and good oral bioavailability with dose-dependent drug exposure level in multiple animal species.
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