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Quantifying ultra-rare pre-leukemic clones via targeted error-corrected sequencing

3 Feb 2015

Abstract excerpt

The quantification of rare clonal and subclonal populations from a heterogeneous DNA sample has multiple clinical and research applications for the study and treatment of leukemia. Specifically, in the hematopoietic compartment, recent reports demonstrate the presence of subclonal variation in normal and malignant hematopoiesis, 1 , 2 and leukemia is now recognized as an oligoclonal disease. 3 Currently, clonal...

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PMID: 25644247
DOI: 10.1038/leu.2015.17

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