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Article

COMT haplotypes modulate associations of antenatal maternal anxiety and neonatal cortical morphology.

The American journal of psychiatry - 1 Feb 2015

Qiu Anqi, Tuan Ta Anh, Ong Mei Lyn, Li Yue, Chen Helen, Rifkin-Graboi Anne, Broekman Birit F P, Kwek Kenneth, Saw Seang-Mei, Chong Yap-Seng, Gluckman Peter D, Fortier Marielle V, Holbrook Joanna Dawn, Meaney Michael J

Abstract excerpt

OBJECTIVE: Exposure to antenatal maternal anxiety and complex genetic variations may shape fetal brain development. In particular, the catechol-O-methyltransferase (COMT) gene, located on chromosome 22q11.2, regulates catecholamine signaling in the prefrontal cortex and is implicated in anxiety, pain, and stress responsivity. This study examined whether individual single-nucleotide polymorphisms (SNPs) of the...

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Source

Identifiers

PMID: 25320962
DOI: 10.1176/appi.ajp.2014.14030313

Genes

COMT
GAA

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