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Article

The BDNF Val66Met polymorphism and plasma brain-derived neurotrophic factor levels in Han Chinese heroin-dependent patients.

Scientific reports - 2 Feb 2015

Chen Shiou-Lan, Lee Sheng-Yu, Chang Yun-Hsuan, Wang Tzu-Yun, Chen Shih-Heng, Chu Chun-Hsien, Chen Po See, Yang Yen Kuang, Hong Jau-Shyong, Lu Ru-Band

Abstract excerpt

BDNF and its gene polymorphism may be important in synaptic plasticity and neuron survival, and may become a key target in the physiopathology of long-term heroin use. Thus, we investigated the relationships between brain-derived neurotrophic factor (BDNF) plasma concentrations and the BDNF Val66Met nucleotide polymorphism (SNP) in heroin-dependent patients. The pretreatment expression levels of plasma BDNF and...

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PMID: 25640280
DOI: 10.1038/srep08148
PMCID: PMC4313085

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BDNF

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