Article
Association of Plasma Pro-Brain-Derived Neurotrophic Factor (proBDNF)/Mature Brain-Derived Neurotrophic Factor (mBDNF) Levels with BDNF Gene Val66Met Polymorphism in Alcohol Dependence.
Medical science monitor : international medical journal of experimental and clinical research - 20 Aug 2021
Mo Min, Fu Xi-Yue, Zhang Xu-Lan, Zhang Shao-Chuan, Zhang Hai-Qing, Wu Li, Li Jia-Lei, Zhou Li
Abstract excerpt
BACKGROUND In a previous study, we reported that pro-brain-derived neurotrophic factor (proBDNF) was involved in the pathology of alcohol dependence, and the single-nucleotide polymorphism (SNP) Val66Met was located at the prodomain of the brain-derived neurotrophic factor gene (BDNF). This polymorphism has been reported to affect intracellular trafficking and activity-dependent secretion of BDNF. Our present...
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