Article
Deletion of Shank1 has minimal effects on the molecular composition and function of glutamatergic afferent postsynapses in the mouse inner ear.
Hearing research - 1 Mar 2015
Braude Jeremy P, Vijayakumar Sarath, Baumgarner Katherine, Laurine Rebecca, Jones Timothy A, Jones Sherri M, Pyott Sonja J
Abstract excerpt
Shank proteins (1-3) are considered the master organizers of glutamatergic postsynaptic densities in the central nervous system, and the genetic deletion of either Shank1, 2, or 3 results in altered composition, form, and strength of glutamatergic postsynapses. To investigate the contribution of Shank proteins to glutamatergic afferent synapses of the inner ear and especially cochlea, we used immunofluorescence...
Topics
- Animals
- Auditory Pathways
- Cochlea
- Ear, Inner
- Evoked Potentials, Auditory, Brain Stem
- Genotype
- Glutamic Acid
- Hair Cells, Auditory, Inner
- Mice, 129 Strain
- Mice, Inbred C57BL