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Article

Ganglioside-Dependent Neural Stem Cell Proliferation in Alzheimer's Disease Model Mice.

ASN neuro - 1 Jan 2000

Koon Noah A, Itokazu Yutaka, Yu Robert K

Abstract excerpt

The aggregation and formation of amyloid plaques by amyloid β-peptides (Aβs) is believed to be one of the pathological hallmarks of Alzheimer's disease (AD). Intriguingly, Aβs have also been shown to possess proliferative effects on neural stem cells (NSCs). Many essential cellular processes in NSCs, such as fate determination and proliferation, are heavily influenced by cell surface glycoconjugates, including...

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Identifiers

PMID: 26699276
DOI: 10.1177/1759091415618916
PMCID: PMC4710121

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