Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8

21 Apr 2009

Abstract excerpt

Senescence is a cellular program that irreversibly arrests the proliferation of damaged cells and induces the secretion of the inflammatory mediators IL- 6 and IL-8 which are part of a larger senescence associated secretory phenotype (SASP). We screened quiescent and senescent human fibroblasts for differentially expressed microRNAS (miRNAs) and found that miRNAs 146a and 146b (miR-146a/b) were significantly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Advanced biosensing and bioanalysis techniques
Share to MicroRNA in disease regulation
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20148189
DOI: 10.18632/aging.100042

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8PMID 20148189Read ↗

Modulation of Inflammatory Markers by miR-146a during Replicative Senescence in Trabecular Meshwork CellsSemantic proximity Read ↗

SIRT1 suppresses the senescence-associated secretory phenotype through epigenetic gene regulation.Semantic proximity Read ↗

Mechanisms and application strategies of miRNA‑146a regulating inflammation and fibrosis at molecular and cellular levels (Review)Semantic proximity Read ↗

IL-6-STAT3 signaling and premature senescenceSemantic proximity Read ↗

MicroRNA-146a acts as a guardian of the quality and longevity of hematopoietic stem cells in miceSemantic proximity Read ↗

MiR-146a as marker of senescence-associated pro-inflammatory status in cells involved in vascular remodellingSemantic proximity Read ↗

MicroRNA‐570 is a novel regulator of cellular senescence and inflammagingSemantic proximity Read ↗

Tumor Suppressor and Aging Biomarker p16INK4a Induces Cellular Senescence without the Associated Inflammatory Secretory PhenotypeSemantic proximity Read ↗

Insulin-like growth factor binding protein-6 delays replicative senescence of human fibroblastsSemantic proximity Read ↗

Klotho suppresses RIG-I-mediated senescence-associated inflammation.Semantic proximity Read ↗

Suppression of p16 alleviates the senescence-associated secretory phenotypeSemantic proximity Read ↗

MicroRNA-216a induces endothelial senescence and inflammation via Smad3/IκBα pathway.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.