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Chikungunya virus evolution following a large 3′UTR deletion results in host-specific molecular changes in protein-coding regions

1 Jan 2018

Abstract excerpt

The 3'untranslated region (UTR) in alphavirus genomes functions in virus replication and plays a role in determining virus host range. However, the molecular evolution of virus UTRs is understudied compared to the evolution of protein-coding regions. Chikungunya virus (CHIKV) has the longest 3'UTR among the alphaviruses (500-700 nt), and 3'UTR length and sequence structure vary substantially among different CHIKV...

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PMID: 29942653
DOI: 10.1093/ve/vey012

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