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γδ TCRs Function as Innate-like Receptors in the Bovine γδ T Cell Response against Leptospira

1 Nov 2022

Abstract excerpt

Leptospira serovar Hardjo are bacterial pathogens of cattle that also cause zoonotic disease in humans. Vaccine-mediated protection against Leptospira serovar Hardjo in cattle is associated with a workshop cluster 1 (WC1)+ γδ T cell response that can be recalled in vitro from PBMC by antigenic stimulation. This provides a model system in which to examine protective vaccine-induced γδ T cell responses in a γδ T...

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PMID: 36426936
DOI: 10.4049/jimmunol.2200319

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