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Article

Systemic and Cerebral Iron Homeostasis in Ferritin Knock-Out Mice

28 Jan 2015

Abstract excerpt

Ferritin, a 24-mer heteropolymer of heavy (H) and light (L) subunits, is the main cellular iron storage protein and plays a pivotal role in iron homeostasis by modulating free iron levels thus reducing radical-mediated damage. The H subunit has ferroxidase activity (converting Fe(II) to Fe(III)), while the L subunit promotes iron nucleation and increases ferritin stability. Previous studies on the H gene (Fth) in...

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PMID: 25629408
DOI: 10.1371/journal.pone.0117435

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