Article
Tissue-specific expression of ferritin H regulates cellular iron homoeostasis in vivo.
The Biochemical journal - 1 May 2006
Wilkinson John, Di Xiumin, Schönig Kai, Buss Joan L, Kock Nancy D, Cline J Mark, Saunders Thomas L, Bujard Hermann, Torti Suzy V, Torti Frank M
Abstract excerpt
Ferritin is a ubiquitously distributed iron-binding protein. Cell culture studies have demonstrated that ferritin plays a role in maintenance of iron homoeostasis and in the protection against cytokine- and oxidant-induced stress. To test whether FerH (ferritin H) can regulate tissue iron homoeostasis in vivo, we prepared transgenic mice that conditionally express FerH and EGFP (enhanced green fluorescent...
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