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Article

Both domain 19 and domain 20 of factor H are involved in binding to complement C3b and C3d.

Molecular immunology - 1 May 2010

Bhattacharjee Arnab, Lehtinen Markus J, Kajander Tommi, Goldman Adrian, Jokiranta T Sakari

Abstract excerpt

Factor H (FH) regulates the alternative pathway of complement in plasma and mediates discrimination of cellular surfaces to alternative pathway activators and non-activators. The carboxyl-terminal domains 19 and 20 of FH are essential in target discrimination and are known to contain binding sites for the C3d part of C3b, heparin, and endothelial cells. Mutations in FH19-20 are frequently found in patients with...

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Identifiers

PMID: 20378178
DOI: 10.1016/j.molimm.2010.03.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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