Cyclic nucleotide phosphodiesterase‐1C (PDE1C) drives cell proliferation, migration and invasion in glioblastoma multiforme cells in vitro

Abstract excerpt

Cyclic nucleotides (cAMP & cGMP) are critical intracellular second messengers involved in the transduction of a diverse array of stimuli and their catabolism is mediated by phosphodiesterases (PDEs). We previously detected focal genomic amplification of PDE1C in >90 glioblastoma multiforme (GBM) cells suggesting a potential as a novel therapeutic target in these cells. In this report, we show that genomic gain of...

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