A genetic variant regulating miR-126 is associated with sight threatening diabetic retinopathy.

doi:10.1177/1479164114560160

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Article

A genetic variant regulating miR-126 is associated with sight threatening diabetic retinopathy.

Diabetes & vascular disease research - 1 Mar 2015

McAuley Annie K, Dirani Mohamed, Wang Jie Jin, Connell Paul P, Lamoureux Ecosse L, Hewitt Alex W

Abstract excerpt

BACKGROUND: The regulation of miR-126 by rs4636297 single nucleotide polymorphism (SNP) has been implicated in the pathogenesis of neovascularisation by promoting vascular endothelial growth factor, suggesting it could be associated with sight threatening diabetic retinopathy (STDR), but has not been previously investigated or reported. MATERIALS AND METHODS: A case control study of 531 individuals with diabetes...

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PMID: 25616704
DOI: 10.1177/1479164114560160

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