Article
Promoter polymorphisms of the pigment epithelium-derived factor gene are associated with diabetic retinopathy.
Biochemical and biophysical research communications - 21 Sept 2007
Iizuka Hiroyuki, Awata Takuya, Osaki Masataka, Neda Tamotsu, Kurihara Susumu, Inoue Kiyoaki, Inukai Kouichi, Kabasawa Sho, Mori Keisuke, Yoneya Shin, Katayama Shigehiro
Abstract excerpt
Pigment epithelium-derived factor (PEDF or SERPINF1), a neuroprotective and anti-angiogenic factor, may play an important role in the pathogenesis of diabetic retinopathy (DR). In 416 patients with type 2 diabetes, four polymorphisms in the PEDF SNPs were identified, rs12150053 and rs12948385 in the promoter region, rs9913583 in the 5'-untranslated region, and rs1136287 (Met72Thr) in exon 3. Based on case-control...
Read the complete abstract on PubMed