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Article

Cyclin A2 regulates erythrocyte morphology and numbers.

Cell cycle (Georgetown, Tex.) - 16 Nov 2016

Jayapal Senthil Raja, Ang Heather Yin-Kuan, Wang Chelsia Qiuxia, Bisteau Xavier, Caldez Matias J, Xuan Gan Xiao, Yu Weimiao, Tergaonkar Vinay, Osato Motomi, Lim Bing, Kaldis Philipp

Abstract excerpt

Cyclin A2 is an essential gene for development and in haematopoietic stem cells and therefore its functions in definitive erythropoiesis have not been investigated. We have ablated cyclin A2 in committed erythroid progenitors in vivo using erythropoietin receptor promoter-driven Cre, which revealed its critical role in regulating erythrocyte morphology and numbers. Erythroid-specific cyclin A2 knockout mice are...

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Identifiers

PMID: 27657745
DOI: 10.1080/15384101.2016.1234546
PMCID: PMC5134699

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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