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Article

Improved detection of resistance at failure to a tenofovir, emtricitabine and efavirenz regimen by ultradeep sequencing

21 Jan 2015

Abstract excerpt

OBJECTIVES: Resistant minority variants present before ART can be a source of virological failure. This has been shown for NRTIs, NNRTIs and CCR5 inhibitors. However, very few data are available for the detection of such minority resistant variants that could be selected at virological failure and not detected using classical Sanger sequencing. METHODS: We studied 26 patients treated with tenofovir, emtricitabine...

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PMID: 25614045
DOI: 10.1093/jac/dku557

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