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Mitochondrial DNA copy number, but not haplogroup is associated with keratoconus in Han Chinese population.

Experimental eye research - 1 Mar 2015

Hao Xiao-Dan, Chen Peng, Wang Ye, Li Su-Xia, Xie Li-Xin

Abstract excerpt

Oxidative stress may play a role in the pathogenesis of keratoconus (KC). Mitochondrial DNA (mtDNA) is closely related to mitochondrion function, and variations may affect the generation of reactive oxygen species (ROS) and be involved in the pathogenesis of KC. To test whether mtDNA background and copy number confer genetic susceptibility to KC in the Han Chinese population, we performed this association study....

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PMID: 25613073
DOI: 10.1016/j.exer.2015.01.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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