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Article

Mitochondrial haplogroup background may influence Southeast Asian G11778A Leber hereditary optic neuropathy.

Investigative ophthalmology & visual science - 1 Jul 2011

Kaewsutthi Supannee, Phasukkijwatana Nopasak, Joyjinda Yutthana, Chuenkongkaew Wanicha, Kunhapan Bussaraporn, Tun Aung Win, Suktitipat Bhoom, Lertrit Patcharee

Abstract excerpt

PURPOSE: To investigate the role of mitochondrial DNA (mt DNA) background on the expression of Leber hereditary optic neuropathy (LHON) in Southeast Asian carriers of the G11778A mutation. METHODS: Complete mtDNA sequences were analyzed from 53 unrelated Southeast Asian G11778A LHON pedigrees in Thailand and 105 normal Thai controls, and mtDNA haplogroups were determined. Clinical phenotypes were tested for...

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PMID: 21398275
DOI: 10.1167/iovs.10-5816

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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