Article
A nonhomogeneous hidden markov model for gene mapping based on next-generation sequencing data.
Journal of computational biology : a journal of computational molecular cell biology - 1 Feb 2015
Ghavidel Fatemeh Zamanzad, Claesen Jürgen, Burzykowski Tomasz
Abstract excerpt
The analysis of polygenetic characteristics for mapping quantitative trait loci (QTL) remains an important challenge. QTL analysis requires two or more strains of organisms that differ substantially in the (poly-)genetic trait of interest, resulting in a heterozygous offspring. The offspring with the trait of interest is selected and subsequently screened for molecular markers such as single-nucleotide...
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