Macroautophagy in sporadic and the genetic form of Parkinson's disease with the A53T α-synuclein mutation

Abstract excerpt

BACKGROUND: The A53T mutation in the α-synuclein gene causes autosomal-dominant Lewy body Parkinson's disease (PD). Cultured cell models have linked this mutation to increased cell macroautophagy, although evidence of enhanced macroautophagy in patients with this mutation has not been assessed. OBJECTIVE: To determine whether macroautophagy is increased by the A53T α-synuclein gene mutation in PD patients and...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Autophagy in Disease and Therapy
• Share to Nuclear Receptors and Signaling
• Share to Parkinson's Disease Mechanisms and Treatments