Article
Joint eQTL assessment of whole blood and dura mater tissue from individuals with Chiari type I malformation.
BMC genomics - 22 Jan 2015
Lock Eric F, Soldano Karen L, Garrett Melanie E, Cope Heidi, Markunas Christina A, Fuchs Herbert, Grant Gerald, Dunson David B, Gregory Simon G, Ashley-Koch Allison E
Abstract excerpt
BACKGROUND: Expression quantitative trait loci (eQTL) play an important role in the regulation of gene expression. Gene expression levels and eQTLs are expected to vary from tissue to tissue, and therefore multi-tissue analyses are necessary to fully understand complex genetic conditions in humans. Dura mater tissue likely interacts with cranial bone growth and thus may play a role in the etiology of Chiari Type...
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