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Article

Bayesian polygenic risk estimation approach to nuclear families with discordant sib-pairs for myelomeningocele.

PloS one - 1 Jan 2024

Aguayo-Gómez Adolfo, Luna-Muñoz Leonora, Svyryd Yevgeniya, Muñoz-Téllez Luis Ángel, Mutchinick Osvaldo M

Abstract excerpt

Myelomeningocele (MMC) is the most severe and disabling form of spina bifida with chronic health multisystem complications and social and economic family and health systems burden. In the present study, we aimed to investigate the genetic risk estimate for MMC in a cohort of 203 Mexican nuclear families with discordant siblings for the defect. Utilizing a custom Illumina array, we analyzed 656 single nucleotide...

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Identifiers

PMID: 39774454
DOI: 10.1371/journal.pone.0316378
PMCID: PMC11684611

Genes

ATIC
C2CD3
DKK2
PLCB2
PSEN2
PSMB4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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