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Multi-omic analysis elucidates the genetic basis of hydrocephalus

1 May 2021

Abstract excerpt

We conducted PrediXcan analysis of hydrocephalus risk in ten neurological tissues and whole blood. Decreased expression of MAEL in the brain was significantly associated (Bonferroni-adjusted p < 0.05) with hydrocephalus. PrediXcan analysis of brain imaging and genomics data in the independent UK Biobank (N = 8,428) revealed that MAEL expression in the frontal cortex is associated with white matter and total brain...

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PMID: 33951428
DOI: 10.1016/j.celrep.2021.109085

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