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Article

The effects of bisphosphonates on ectopic soft tissue mineralization caused by mutations in the ABCC6 gene.

Cell cycle (Georgetown, Tex.) - 1 Jan 2015

Li Qiaoli, Sundberg John P, Levine Michael A, Terry Sharon F, Uitto Jouni

Abstract excerpt

Pseudoxanthoma elasticum (PXE) and generalized arterial calcification of infancy (GACI) are heritable ectopic mineralization disorders. Most cases of PXE and many cases of GACI harbor mutations in the ABCC6 gene. There is no effective treatment for these disorders. We explored the potential effic...

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Source

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Identifiers

PMID: 25607347
DOI: 10.1080/15384101.2015.1007809
PMCID: PMC4615006

Genes

ABCC6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25607347-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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The effects of bisphosphonates on ectopic soft tissue mineralization caused by mutations in the ABCC6 gene.PMID 25607347Read ↗

Pseudoxanthoma elasticum, the paradigm of heritable ectopic mineralization disorders - can diet help?Semantic proximity Read ↗

Inhibition of Tissue-Nonspecific Alkaline Phosphatase Attenuates Ectopic Mineralization in the Abcc6-/- Mouse Model of PXE but Not in the Enpp1 Mutant Mouse Models of GACI.Semantic proximity Read ↗

The mineralization phenotype in Abcc6 ( -/- ) mice is affected by Ggcx gene deficiency and genetic background--a model for pseudoxanthoma elasticum.Semantic proximity Read ↗

The molecular and physiological roles of ABCC6: more than meets the eyeSemantic proximity Read ↗

Mouse models for pseudoxanthoma elasticum: genetic and dietary modulation of the ectopic mineralization phenotypes.Semantic proximity Read ↗

Anticalcification effects of DS-1211 in pseudoxanthoma elasticum mouse models and the role of tissue-nonspecific alkaline phosphatase in ABCC6-deficient ectopic calcification.Semantic proximity Read ↗

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