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Article

Atorvastatin counteracts aberrant soft tissue mineralization in a mouse model of pseudoxanthoma elasticum (Abcc6⁻/⁻).

Journal of molecular medicine (Berlin, Germany) - 1 Oct 2013

Guo Haitao, Li Qiaoli, Chou David W, Uitto Jouni

Abstract excerpt

UNLABELLED: Pseudoxanthoma elasticum (PXE), a multisystem heritable disorder with aberrant mineralization of arterial blood vessels, is caused by mutations in the ABCC6 gene. Previous studies have suggested that carriers of the ABCC6 mutations, particularly of p.R1141X, are at increased risk for coronary artery disease. In this study, we used Abcc6 (tm1Jfk) knock-out mice to determine the serum lipid profiles and...

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Identifiers

PMID: 23807484
DOI: 10.1007/s00109-013-1066-5
PMCID: PMC3783622

Genes

ABCC6

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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