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Somatic cell-derived BMPs induce male germ cell meiosis initiation during embryonic stage via regulating <i>Dazl</i> expression

2020-03-02

Abstract excerpt

Germ cell fate is believed to be determined by the signaling from sexually differentiated somatic cell. However, the molecular mechanism remains elusive. In this study, ectopic initiation of meiosis in male germ cells was observed during embryonic stage by over-activating CTNNB1 in Sertoli cells. Somatic cell transcriptome and single germ cell RNA-seq analysis indicated that TGF-β signaling was activated after CTN...

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Literature Corpus work
b87d71d4-9fa6-52c6-acb1-2d8adcbc6843
DOI
10.1101/2020.03.01.971937
Open publication

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Somatic cell-derived BMPs induce male germ cell meiosis initiation during embryonic stage via regulating <i>Dazl</i> expressionDOI 10.1101/2020.03.01.971937
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