The Acinetobacter baumannii entA gene located outside the acinetobactin cluster is critical for siderophore production, iron acquisition and virulence.

Abstract excerpt

Acinetobacter baumannii causes severe infections in compromised patients, who present an iron-limited environment that controls bacterial growth. This pathogen has responded to this restriction by expressing high-affinity iron acquisition systems including that mediated by the siderophore acinetobactin. Gene cloning, functional assays and biochemical tests showed that the A. baumannii genome contains a single...

Topics

• Acinetobacter baumannii
• Chromosomes, Bacterial
• Cloning, Molecular
• Gene Order
• Genes, Bacterial
• Genetic Loci
• Imidazoles
• Iron
• Molecular Sequence Annotation
• Multigene Family
• Oxazoles