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Article

BBB07 contributes to, but is not essential for, Borrelia burgdorferi infection in mice.

Microbiology (Reading, England) - 1 Oct 2020

Hahn Beth, Anderson Phillip, Lu Zouyan, Danner Rebecca, Zhou Zhipeng, Hyun Noorie, Gao Lihui, Lin Tao, Norris Steven J, Coburn Jenifer

Abstract excerpt

Borrelia burgdorferi, a causative agent of Lyme disease, encodes a protein BBB07 on the genomic plasmid cp26. BBB07 was identified as a candidate integrin ligand based on the presence of an RGD tripeptide motif, which is present in a number of mammalian ligands for β1 and β3 integrins . Previous work demonstrated that BBB07 in recombinant form binds to β1 integrins and induces inflammatory responses in synovial...

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PMID: 32936070
DOI: 10.1099/mic.0.000972
PMCID: PMC7660918

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