Fascin actin bundling controls podosome turnover and disassembly while cortactin is involved in podosome assembly by its SH3 domain in THP-1 macrophages and dendritic cells.

Abstract excerpt

Podosomes are dynamic degrading devices present in myeloid cells among other cell types. They consist of an actin core with associated regulators, surrounded by an adhesive ring. Both fascin and cortactin are known constituents but the role of fascin actin bundling is still unclear and cortactin...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Actin-Related Protein 2-3 Complex
• Share to Actins
• Share to Dendritic Cells