Antibodies against the majority subunit of type IV pili disperse nontypeable H aemophilus influenzae biofilms in a LuxS ‐dependent manner and confer therapeutic resolution of experimental otitis media

Abstract excerpt

Despite resulting in a similar overall outcome, unlike antibodies directed against the DNABII protein, integration host factor (IHF), which induce catastrophic structural collapse of biofilms formed by nontypeable Haemophilus influenzae (NTHI), those directed against a recombinant soluble form of PilA [the majority subunit of Type IV pili (Tfp) produced by NTHI], mediated gradual 'top-down' dispersal of NTHI from...

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