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Redirecting the immune response towards immunoprotective domains of a DNABII protein resolves experimental otitis media

14 Oct 2019

Abstract excerpt

Abstract The chronicity and recurrence of many bacterial diseases is largely attributable to the presence of a biofilm, and eradication of these structures is confounded by an extracellular DNA-rich matrix. DNABII proteins, including integration host factor (IHF), are critical components of the matrix formed by all human pathogens tested to date. Whereas the natural adaptive immune response to IHF is against...

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PMID: 31632744
DOI: 10.1038/s41541-019-0137-1

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