Article
Continuous Microevolution Accelerates Disease Progression during Sequential Episodes of Infection.
Cell reports - 3 Mar 2020
Harrison Alistair, Hardison Rachael L, Fullen Audra R, Wallace Rachel M, Gordon David M, White Peter, Jennings Ryan N, Justice Sheryl S, Mason Kevin M
Abstract excerpt
Bacteria adapt to dynamic changes in the host during chronic and recurrent infections. Bacterial microevolution is one type of adaptation that imparts a selective advantage. We hypothesize that recurrent episodes of disease promote microevolution through genetic mutations that modulate disease severity. We use a pre-clinical model of otitis media (OM) to determine the potential role for microevolution of...
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