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Article

Innovative Research Design Exploring the Effects of Physical Activity and Genetics on Cognitive Performance in Community-Based Older Adults.

Journal of aging and physical activity - 1 Oct 2015

Etnier Jennifer L, Labban Jeffrey D, Karper William B, Wideman Laurie, Piepmeier Aaron T, Shih Chia-Hao, Castellano Michael, Williams Lauren M, Park Se-Yun, Henrich Vincent C, Dudley William N, Rulison Kelli L

Abstract excerpt

Physical activity is predictive of better cognitive performance and lower risk of Alzheimer's disease (AD). The apolipoprotein E gene (APOE) is a susceptibility gene for AD with the e4 allele being associated with a greater risk of AD. Cross-sectional and prospective research shows that physical activity is predictive of better cognitive performance for those at greater genetic risk for AD. However, the...

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Identifiers

PMID: 25594264
DOI: 10.1123/japa.2014-0221
PMCID: PMC4587990

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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