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Article

Maintenance of mouse hematopoietic stem cells ex vivo by reprogramming cellular metabolism

15 Jan 2015

Abstract excerpt

The difficulty in maintaining the reconstituting capabilities of hematopoietic stem cells (HSCs) in culture outside of the bone marrow microenvironment has severely limited their utilization for clinical therapy. This hurdle is largely due to the differentiation of long-term stem cells. Emerging evidence suggests that energy metabolism plays an important role in coordinating HSC self-renewal and differentiation....

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PMID: 25593337
DOI: 10.1182/blood-2014-04-568949

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