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Article

Myostatin and IGF-I signaling in end-stage human heart failure: a qRT-PCR study

15 Jan 2015

Abstract excerpt

BACKGROUND: Myostatin (Mstn) is a key regulator of heart metabolism and cardiomyocyte growth interacting tightly with insulin-like growth factor I (IGF-I) under physiological conditions. The pathological role of Mstn has also been suggested since Mstn protein was shown to be upregulated in the myocardium of end-stage heart failure. However, no data are available about the regulation of gene expression of Mstn and...

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PMID: 25591711
DOI: 10.1186/s12967-014-0365-0

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